As it turns out, I can actually answer this question in detail.
The most shameful thing I ever did was when I was 23 years old. That was the yaer when, in pain and rage after a particular hurtful event, I told God that if He was going to keep doing that stuff to me that I wanted him to butt out off my life. What followed was a formative experience for me.
The following year, with no external changes, was spent in depresion, alcoholism, and general debauchery. My anger level instantly jumped. I turned to many things for comfort, and none worked. The whole time I could physically feel an emptiness at my core that I did not recognize. All of this was completely new to me, having become a born again Christian at a very young age. The change was instantaneous, as in the very next morning.
I spent an entire year like this. 8 months in God began to call me back, I could feel it in my motivation, if that makes any sense. I got this urge that I had never had before to start reading my Bible in an intensive manner, and actually read the whole thing from cover to cover, a feat I had never even been interested in attempting before. I starting going to church again, and even joined a Bible study group for young adults. I hadn't bothered with Wednesday Bible study one time in my adult life until this point.
As I read and pondered God's Word I was granted an understanding that was deeper than I had ever known before. It was as if the Word had only been partially open to my understanding before. After about 4 months of this, like the prodigal son, I realized just how far gone I was, how lost I had become, and came running back to my God. I have never looked back since.
I'm sure that someone standing on the outside can, and will rationalize these events in some way that does not require the involvement of God. The deep internal happenings are hard to describe, and require the personal experience to fully apreciate. What I have said here, despite the details, is actualy more of a brief synopsis than a detailed telling. I can say with absolute certainty and authority that there is not one thing in my life that remained the same when I told God to leave me alone. Let me assure that all of what I have written here is true.
That year was a formative experience that, in hindsight, I am actually very grateful for. It showed me exactly what Jesus has done to free me from sin in my own life. It showed me that what is good in my life is not of my own will and effort, but a gift from God Himself. I know because none of it existed without Him. Take it for what you will.